I am afraid
@stuartbuck1 is getting multiple comparisons wrong. If you want outcome X AND Y AND Z to be significant (as in the example) you do not correct so the problem never happens. You correct if you want X OR Y OR Z to show an effect.
I'm not a fan of multiple comparisons corrections (e.g., Bonferroni, Benjamini-Hochberg, etc.). Just preregister everything and report all results (or else do some kind of multiverse analysis or specification curve), and let the reader decide.
One of the biggest issues for me is the following paradox.
Say I run an RCT testing a drug as to LDL levels, and I'm trying to decide what outcomes to measure: reduction in LDL over 1 year, cardiac outcomes over 3 years, or mortality over 5 years. Suppose I measure all three, and the trial ultimately shows a reduction in all of those outcomes (p=.04 for each).
With Bonferroni etc., the trial would report a "null" effect across the board, even though these outcomes are all consistent and mutually reinforcing, and the evidence for the treatment is way stronger than if I had only collected evidence on cholesterol levels at 1 year.
It makes no sense to me that any single outcome by itself would have been statistically significant, but just because, in the past, I decided to collect more and better evidence, now the treatment has "no effect"?