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Common sources of bias in variant effect predictor benchmarking are assessed using data from #deepmutationalscanning experiments ➡️ embopress.org/doi/full/10.15… @jmarshlab @MRC_HGU @EdinUni_IGC @EdinburghUni #geneticvariant
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Escape Mutants vs #Bebtelovimab (LY-CoV1404) - new data from #DeepMutationalScanning of #Omicron Variants H/T @tylernstarr
Our newest study is up, where we report deep mutational scanning data in the Omicron BA.1 and BA.2 receptor-binding domains biorxiv.org/content/10.1101/…
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It takes advantage of the massively parallel nature of #DeepMutationalScanning to quantify the phenotypic effects of thousands of perturbations in: 1. Multiple phenotypic assays - bindingPCA & abundacePCA 2. Multiple genetic backgrounds - most singles and few double AA subs
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🔥Hot off the press! "Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers" #Multiplexassay #deepmutationalscanning #varianteffect @kmatreyek @dougfowler42 bit.ly/3mXIOM7
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#DeepMutationalScanning data (covering 6,291 positions in 30 proteins) are combined & the consequences of mutation at each position are used to define a mutational landscape & explore aa functions --> bit.ly/3ruvW1U @pedrobeltrao @Ally_Dunham @emblebi #ProteinStructure
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#ScienceJobs: Postdoctoral Scholar in genomics (Center for the Multiplex Assessment of Phenotype, @CEGS_CMAP) University of Washington and the University of Toronto, Seattle, USA jobrxiv.org/job/university-o… #Postdocs #deepmutationalscanning #molecularbiology #proteomics
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Be sure to register for the upcoming DMS symposium and workshop held here in Seattle, Jan 13th and 14th 2020. (Admission is free) #DeepMutationalScanning,#PrecisonMedicine, @BrotmanBaty,@uwgenome prnewswire.com/news-releases…
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#deepmutationalscanning is the theme of the morning #EMBOmodularity18 was expecting to be way out of my depth but the first talk by #TanjaKortemme @UCSF is beautifully clear and has structures! #Ran #Gsp1 #GEF #GAP #allostery also the first #NMR spectrum of conf #31P
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